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Zhuang, Xiaoxi
One or more keywords matched the following properties of Zhuang, Xiaoxi
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overview We investigate the molecular machinery underlying synaptic plasticity and information processing in the brain. We are especially interested in synaptic mechanisms supporting reinforcement learning and motor control. Our main approaches include mouse genetics, fly genetics, optogenetics, animal learning paradigms, electrophysiology, molecular biology and RNA-seq.
One or more keywords matched the following items that are connected to Zhuang, Xiaoxi
Item TypeName
Concept Mice, Transgenic
Concept Mice, Inbred C57BL
Concept Mice, Knockout
Concept Mice
Concept Mice, 129 Strain
Concept Mice, Mutant Strains
Academic Article Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice.
Academic Article Targeted gene expression in dopamine and serotonin neurons of the mouse brain.
Academic Article Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice.
Academic Article Adenylyl cyclase type 5 contributes to corticostriatal plasticity and striatum-dependent learning.
Academic Article Dopamine scales performance in the absence of new learning.
Academic Article Dopamine-dependent motor learning: insight into levodopa's long-duration response.
Academic Article Dopaminergic enhancement of local food-seeking is under global homeostatic control.
Academic Article Taste uncoupled from nutrition fails to sustain the reinforcing properties of food.
Academic Article A cAMP pathway underlying reward prediction in associative learning.
Academic Article A role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson's disease.
Academic Article A53T human a-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration.
Academic Article Cyclic AMP and afferent activity govern bidirectional synaptic plasticity in striatopallidal neurons.
Academic Article Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency.
Academic Article Low Dopamine D2 Receptor Increases Vulnerability to Obesity Via Reduced Physical Activity, Not Increased Appetitive Motivation.
Academic Article Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Academic Article Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by In Vitro Cellular Studies and In Vivo PET Imaging.
Grant Drosophila and mouse models of PNPO deficiency
Grant Reward mechanisms in feeding and obesity
Grant Dynamics of m6A methylated Arc mRNA
Grant RNA methylation in synaptic plasticity and drug-seeking
Grant Targeting adenylyl cyclase to prevent L-DOPA-induced dyskinesia
Grant Animal models of dopamine-independent motor control
Grant Gene Dose Effect of DJ-1 and PINK1 on Tissue Degeneration
Grant Genomic analysis of feeding behavior and fitness in Drosophila
Grant MUTAGENESIS PERMITTING CONTROLLED GENE EXPRESSION
Grant Genetic dissection of neural pathways for appetitive associative learning
Grant GENETIC AND BEHAVIORAL DISSECTION OF INHIBITORY CONTROL
Grant Generating mouse models with cell type-specific and reversible GABA deficiency
Search Criteria
  • mouse
  • genetics